Detalhe da pesquisa
1.
High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo.
J Biol Chem
; 300(2): 105618, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38176652
2.
A pairwise approach to revitalize ß-lactams for the treatment of TB.
Antimicrob Agents Chemother
; : e0003424, 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38690896
3.
Pharmacological validation of dihydrofolate reductase as a drug target in Mycobacterium abscessus.
Antimicrob Agents Chemother
; 68(1): e0071723, 2024 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38018963
4.
Peritoneal sepsis caused by Escherichia coli triggers brainstem inflammation and alters the function of sympatho-respiratory control circuits.
J Neuroinflammation
; 21(1): 45, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38331902
5.
Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F420H2-dependent reduction.
Proc Natl Acad Sci U S A
; 118(25)2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34161270
6.
Oral ß-lactam pairs for the treatment of Mycobacterium avium complex pulmonary disease.
J Infect Dis
; 2023 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38150401
7.
Side-by-Side Profiling of Oxazolidinones to Estimate the Therapeutic Window against Mycobacterial Infections.
Antimicrob Agents Chemother
; 67(4): e0165522, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36920191
8.
ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate.
Antimicrob Agents Chemother
; 67(9): e0038123, 2023 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37493373
9.
Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection.
Antimicrob Agents Chemother
; 67(2): e0145922, 2023 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36688684
10.
A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Anti-Mycobacterial Activity.
Antimicrob Agents Chemother
; 95(5)2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33558292
11.
Anti-Mycobacterium abscessus Activity of Tuberculosis F-ATP Synthase Inhibitor GaMF1.
Antimicrob Agents Chemother
; 66(5): e0001822, 2022 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35481752
12.
Strongly Bactericidal All-Oral ß-Lactam Combinations for the Treatment of Mycobacterium abscessus Lung Disease.
Antimicrob Agents Chemother
; 66(9): e0079022, 2022 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36047786
13.
Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro.
Antimicrob Agents Chemother
; 66(12): e0123722, 2022 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36350151
14.
Cyclohexyl-griselimycin Is Active against Mycobacterium abscessus in Mice.
Antimicrob Agents Chemother
; 66(1): e0140021, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34723632
15.
Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus.
Antimicrob Agents Chemother
; 66(9): e0066922, 2022 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36005813
16.
Structural Elements Involved in ATP Hydrolysis Inhibition and ATP Synthesis of Tuberculosis and Nontuberculous Mycobacterial F-ATP Synthase Decipher New Targets for Inhibitors.
Antimicrob Agents Chemother
; 66(12): e0105622, 2022 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36445139
17.
A Rabbit Model to Study Antibiotic Penetration at the Site of Infection for Nontuberculous Mycobacterial Lung Disease: Macrolide Case Study.
Antimicrob Agents Chemother
; 66(3): e0221221, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35099272
18.
Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.
Bioorg Med Chem
; 74: 117046, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36228522
19.
Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance.
Proc Natl Acad Sci U S A
; 116(39): 19665-19674, 2019 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31488707
20.
Why Matter Matters: Fast-Tracking Mycobacterium abscessus Drug Discovery.
Molecules
; 27(20)2022 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36296540